Everolimus – High-Purity CRM for LC-MS/MS (CAS 159351-69-6)
Everolimus (RAD001, CAS 159351-69-6) is an mTOR inhibitor used for immunosuppression in solid organ transplantation and as an antineoplastic agent. ReChem Labs supplies Everolimus as a primary Certified Reference Material (CRM) at ≥99.2% purity determined by orthogonal HPLC and qNMR methods, fully compliant with ISO 17511 metrological traceability requirements.
The dual-method certification (HPLC + qNMR) provides maximum analytical confidence for laboratories requiring rigorous validation documentation. The comprehensive COA includes: absolute purity assignment with expanded uncertainty (k=2), HPLC purity chromatogram, qNMR spectrum with integration data, residual solvent analysis, water content, and structural identity by LC-HRMS.
Applications include: LC-MS/MS method validation and verification for whole-blood Everolimus TDM, ISO 15189-accredited clinical laboratory calibration, EQAS and proficiency testing programs, and combined immunosuppressant panel development for post-transplant monitoring.
Product Specifications
| CAS Number | 159351-69-6 |
| Molecular Formula | C₅₃H₈₃NO₁₄ |
| Purity | ≥99.2% (HPLC + qNMR) |
| Standard Type | CRM — ISO 17511 Compliant |
| Storage | −20°C, protect from light |
| Pack Sizes | 5 mg | 10 mg | 25 mg |
| Documentation | COA (expanded uncertainty), SDS, LC-HRMS identity, ISO 17511 traceability |
Key Features
- Purity ≥99.2% by dual orthogonal methods: HPLC and qNMR
- ISO 17511 compliant — full metrological traceability documentation
- Expanded uncertainty (k=2) reported in COA per GUM guidelines
- Identity confirmed by LC-HRMS (LC high-resolution mass spectrometry)
- Suitable for ISO 15189 accredited TDM labs and EQAS programs
- Same-day dispatch from Houston, TX (orders placed before 2 PM CST)
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