Sirolimus – Primary CRM, qNMR Certified (CAS 53123-88-9)
Sirolimus (Rapamycin, CAS 53123-88-9) is an mTOR inhibitor used in transplant immunosuppression and oncology research. ReChem Labs supplies Sirolimus as a primary Certified Reference Material (CRM) certified by quantitative NMR (qNMR) at ≥99.3% purity, in compliance with USP and Ph. Eur. reference standard specifications.
The qNMR-based certification approach provides a primary, absolute purity determination independent of reference standards — delivering the highest metrological confidence for method validation, calibrator preparation, and regulatory submissions. Each lot is accompanied by a comprehensive characterization report covering ¹H-qNMR purity, HPLC profile, residual solvents (GC-HS), water content (KF), and IR identity confirmation.
Sirolimus CRM applications include: LC-MS/MS method development and validation for whole-blood TDM in transplant patients, USP assay monograph compliance testing, proficiency testing and EQAS programs, and stability studies for immunosuppressant QC panels.
Product Specifications
| CAS Number | 53123-88-9 |
| Molecular Formula | C₅₁H₇₉NO₁₃ |
| Purity | ≥99.3% (qNMR) |
| Standard Type | CRM — USP / Ph. Eur. Compliant |
| Storage | −20°C, protect from light |
| Pack Sizes | 5 mg | 10 mg | 25 mg |
| Documentation | qNMR Characterization Report, COA, SDS, NIST-Traceable Certificate |
Key Features
- Purity ≥99.3% by qNMR — absolute primary determination, no reference dependence
- USP and Ph. Eur. reference standard compliant
- NIST/BIPM-traceable with full ¹H-qNMR characterization report
- Ideal for LC-MS/MS TDM validation, USP monograph compliance, and EQAS
- Includes HPLC profile, residual solvents (GC-HS), and KF water content data
- Same-day dispatch from Houston, TX (orders placed before 2 PM CST)
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